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Congenital condition in which the colon does not have the normal network of nerves; there is little urge to defecate so the feces accumulate and cause megacolon.
Results: Patients with ARM or Hirschsprung'sdisease did not differ in their quality of life.
2
Enterocolitis continues to be the major cause of morbidity and mortality in patients with Hirschsprung'sdisease.
3
Conclusions: The quality of life of patients with ARM or Hirschsprung'sdisease was found to be comparable.
4
Additionally, an extensive medical evaluation to look for physiological causes for chronic constipation, including Hirschsprung'sdisease, was not diagnostic.
5
Finally, we used this system to investigate the cellular and molecular basis for Hirschsprung'sdisease caused by a mutation in the gene PHOX2B.